Abcam, ab232728, Anti-PGRPS antibody

Size: 100µg
Rabbit Polyclonal PGRPS antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Rat, Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Rat Pglyrp1 aa 1 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Rat, Human,
Applications:WB, IHC-P, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Rat Pglyrp1 aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q9JLN4

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-Antigen-specific affinity chromatography followed by Protein A affinity chromatography., Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 55.77% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Peptidoglycan Recognition Proteins (PGRPs) are pattern recognition receptors known for their role in innate immunity. Some alternate names for PGRPs include PGLYRPs. These proteins identify bacterial peptidoglycans triggering immune responses. PGRPs have varying molecular masses that range typically between 20 to 25 kDa. Expression of PGRPs occurs in several tissues including skin eyes liver and throughout the gastrointestinal tract.
Biological function summary
Functioning in innate immunity PGRPs bind to bacterial cell wall components such as peptidoglycan and lipopolysaccharides. When PGRPs detect these molecules they can activate immune responses to neutralize pathogens. Some PGRPs can also act as amidases breaking down peptidoglycans. PGRPs do not usually act alone; they are part of complexes with other immune proteins to enhance pathogen recognition and response.
Pathways
PGRPs play significant roles in the immune pathway and inflammatory signaling pathways. They interact with the toll-like receptor pathways to mediate responses to bacterial infections. PGRPs also link with Nod proteins to modulate the immune response upon detecting peptidoglycans. These pathways help coordinate an effective defense against infection.
PGRPs’ malfunction or dysregulation links with inflammatory bowel disease and psoriasis. Altered PGRP levels correlate with changes in the gut flora contributing to inflammatory bowel disease. In psoriasis PGRPs’ improper function may exacerbate skin inflammation because they interact with proteins like IL-6 and TNF-alpha. Such interactions highlight their potential as therapeutic targets for these conditions.