Abcam, ab232756, Anti-FIGN/Fidgetin antibody

Size: 100µg
Rabbit Polyclonal FIGN/Fidgetin antibody. Suitable for WB, IHC-P and reacts with Human, Recombinant full length protein - Human, Pig samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human FIGN aa 1-350.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human, Pig,
Applications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human FIGN aa 1-350. The exact immunogen used to generate this antibody is proprietary information.Q5HY92

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-Antigen-specific affinity chromatography followed by Protein A affinity chromatography., Storage buffer-pH: 7.4Preservative: 0.011% Proclin 300Constituents: PBS, 55.77% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Fidgetin also known as FIGN is a protein that plays a role in microtubule dynamics. It belongs to the AAA ATPase family and has a molecular mass of approximately 88 kDa. Fidgetin is primarily expressed in the nervous system and various other tissues including the lung and liver. It seems to regulate microtubule severing which is important for various cellular processes such as mitosis and intracellular transport.
Biological function summary
Fidgetin modulates the cytoskeleton by remodeling microtubules which affects cell shape and motility. This protein acts as a part of the broader microtubule-severing complex influencing both cellular division and structural organization. Its activities impact how cells can respond to changes in their environment particularly in nerve and muscle cells where precise structural adjustments are essential.
Pathways
Fidgetin has important roles in the regulation of the cytoskeleton specifically within microtubule-associated pathways. Fidgetin-related pathways typically involve interactions with tubulin and katanin another protein to manage microtubule length and distribution. Microtubule severing by Fidgetin aligns closely with pathways controlling cell cycle progression and intracellular transport ensuring effective cell functioning.
Fidgetin's disruption can relate to neurological disorders due to its influence on nervous system structure. For instance abnormalities in Fidgetin activity may be linked to neurodegenerative diseases where microtubule integrity becomes compromised. Additionally cancer can feature altered Fidgetin expression where its interaction with proteins like katanin can affect abnormal cell division and invasion contributing to tumor progression.