Abcam, ab232983, Anti-QDPR/DHPR antibody

Size: 100µg
Rabbit Polyclonal QDPR/DHPR antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Recombinant fragment - Human, Rat, Pig, Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human QDPR.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Rat, Human, Pig,
Applications:ICC/IF, IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Full Length Protein corresponding to Human QDPR.P09417

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-Antigen-specific affinity chromatography followed by Protein A affinity chromatography., Storage buffer-pH: 7.4Preservative: 0.011% Proclin 300Constituents: PBS, 55.77% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
QDPR also known as Quinoid Dihydropteridine Reductase or DHPR is an enzyme that plays an important role in tetrahydrobiopterin (BH4) regeneration. It has a molecular mass of approximately 25 kDa and is found in various tissues such as the liver and brain where it contributes to neurotransmitter synthesis and other physiological processes. The DHPR protein is encoded by the QDPR gene in humans and is highly conserved across species indicating its essential function.
Biological function summary
QDPR catalyzes the reduction of quinonoid dihydrobiopterin (qBH2) to tetrahydrobiopterin maintaining BH4 homeostasis. This process supports neurotransmitter synthesis by replenishing BH4 a cofactor for aromatic amino acid hydroxylases. QDPR does not operate as part of a large multi-protein complex but has a significant role as a standalone enzyme that assists hydroxylating enzymes important for dopamine serotonin and nitric oxide production.
Pathways
QDPR contributes to the biosynthesis of catecholamines and serotonin both essential neurotransmitter pathways. It supports phenylalanine hydroxylase tyrosine hydroxylase and tryptophan hydroxylase activities by sustaining BH4 levels. These pathways are integral to proper neurological function and are tightly regulated due to their dependence on QDPR's enzymatic activity. The function of QDPR aligns with the regulation of neurotransmitter metabolism working alongside other critical proteins in these pathways.
QDPR deficiency can result in hyperphenylalaninemia a condition characterized by elevated phenylalanine levels leading to cognitive impairments. This deficiency affects neurotransmitter synthesis linking it to neurological diseases such as depressive disorders. Additionally QDPR-related disruptions can implicate other proteins like phenylalanine hydroxylase showing how these metabolic pathways and their components are interwoven into broader physiological contexts.