Abcam, ab233280, Anti-PABPC1L antibody

Size: 100µg
Rabbit Polyclonal PABPC1L antibody. Suitable for WB, IHC-P and reacts with Rat, Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human PABPC1L aa 500 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Rat, Human,
Applications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human PABPC1L aa 500 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q4VXU2

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Purification notes-ab233280 was purified by antigen-specific affinity chromatography followed by Protein A affinity chromatography., Storage buffer-pH: 7.4Preservative: 0.011% Proclin 300Constituents: PBS, 55.77% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
PABPC1L also known as cytoplasmic poly(A)-binding protein 1-like is a protein encoded by the PABPC1L gene. It weighs approximately 72 kDa. This protein binds to the poly(A) tail of mRNA molecules facilitating the regulation of mRNA stability and translation. PABPC1L shows expression in various tissues with notable expression in testis and oocytes where it functions during gametogenesis.
Biological function summary
PABPC1L influences mRNA metabolic processes and is important during oocyte maturation and early embryogenesis. It acts as a regulator of mRNA decay and translation control most likely as part of larger ribonucleoprotein complexes. By connecting with other RNA-binding proteins PABPC1L helps modulate translational control during the transition from a quiescent oocyte to an activated embryo facilitating proper development stages.
Pathways
PABPC1L participates in mRNA surveillance and translational control. It notably operates in pathways like the mRNA decay pathway where it works closely with other proteins including eukaryotic initiation factors. PABPC1L interacts with such factors to fine-tune the balance between mRNA translation and degradation impacting protein synthesis in embryonic cells.
PABPC1L has connections with reproductive and developmental conditions. Aberrant expression may link to impaired gamete formation and fertility issues. Its association with other RNA-binding proteins reinforces connections to reproductive disorders. Additionally PABPC1L's role in early embryonic development suggests potential links to embryogenesis disorders where proper mRNA regulation is critical.