Abcam, ab233288, Anti-Thromboxane A2 receptor/TBXA2R antibody - Cytoplasm Marker

Size: 100µg
Rabbit Polyclonal Thromboxane A2 receptor/TBXA2R antibody. Cytoplasm marker. Suitable for WB, IHC-P and reacts with Rat, Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human TBXA2R aa 1 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Rat, Human,
Applications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human TBXA2R aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.P21731

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Purification notes-Antigen-specific affinity chromatography followed by Protein A affinity chromatography., Storage buffer-pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 55.77% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The Thromboxane A2 receptor (TBXA2R) also known as the thromboxane prostanoid receptor is a G protein-coupled receptor with a molecular mass of approximately 70 kDa. This receptor is important for mediating the effects of thromboxane A2 a lipid-derived molecule involved in vasoconstriction and platelet aggregation. TBXA2R expresses predominantly in platelets smooth muscle cells and in some types of leukocytes. The receptor's activity is mediated through Gq proteins causing changes in intracellular calcium levels which trigger various cellular responses.
Biological function summary
Within the context of cellular signaling TBXA2R plays vital roles in hemostasis and thrombosis through its impact on platelet activation and vascular tone regulation. When thromboxane A2 binds to TBXA2R the receptor undergoes conformational changes activating intracellular signaling cascades that facilitate these physiological processes. TBXA2R operates as part of a signaling complex that includes other receptors and regulatory proteins modulating hemostatic balance and vascular reactivity.
Pathways
This receptor fits centrally into the arachidonic acid pathway influencing hemostatic and inflammatory responses. It closely interacts with cyclooxygenase enzymes particularly COX-1 involved in thromboxane A2 synthesis. TBXA2R also integrates into the prostaglandin synthesis pathway interacting with related prostanoid receptors sharing similar signaling mechanisms but differing physiological outcomes. These pathways reveal TBXA2R's significance as a cytoplasmic marker for activity related to vascular homeostasis.
TBXA2R exhibits key associations with cardiovascular diseases including atherosclerosis and myocardial infarction. The receptor’s role in promoting platelet aggregation makes it an interesting target in these pathologies where abnormal clotting adds to disease progression. Additionally TBXA2R connects with other proteins like integrins and inhibitors of cyclooxygenase representing therapeutic targets to modulate its activity and prevent thrombotic events and inflammatory responses associated with these conditions.