Abcam, ab233388, Anti-SAGE1 antibody [EPR21747]

Size: 20µL / 100µL / 1mL
Rabbit Recombinant Monoclonal SAGE1 antibody. Suitable for IHC-P, mIHC and reacts with Human samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR21747,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, mIHCSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The SAGE1 protein also known as Sarcoma Antigen Gene 1 has a molecular weight of approximately 29 kDa. It is primarily expressed in the testis with occasional expression in certain tumor types. SAGE1 belongs to the cancer/testis antigen family indicating its role in reproductive or tumor-specific functions. Researchers find it predominantly expressed in various types of sarcomas and some cancers drawing attention to its role in oncological studies.
Biological function summary
The SAGE1 protein shows expression linked to cellular processes specific to testis development and potentially in tumorigenesis. It might be part of a complex influencing cellular differentiation and proliferation. Studies indicate that SAGE1 has roles in cell signaling pathways that help modulate gene expression. Researchers continue to investigate its involvement in linking normal physiological functions within testis tissues to aberrations seen in cancerous transformations.
Pathways
Research focuses on the involvement of SAGE1 in signaling pathways like the MAPK pathway and possibly the PI3K/AKT pathway. These pathways are significant in cell division and survival providing possible mechanisms where SAGE1 affects cellular behavior. The MAPK pathway associates SAGE1 with proteins like RAF and MEK while in the PI3K/AKT pathway proteins like AKT1 might interact reflecting the influence of SAGE1 on cell growth and survival.
Researchers note significant correlations between SAGE1 expression and certain cancers particularly sarcomas and testicular cancer. The expression of SAGE1 in these conditions suggests it as a potential biomarker for diagnosis or treatment targets. In cancerous states the presence of SAGE1 connects with altered pathways involving proteins such as BCL2 which impacts cell apoptosis emphasizing its role in the pathology of these diseases.