Abcam, ab233510, Anti-LCN8 antibody

Size: 100µg
Rabbit Polyclonal LCN8 antibody. Suitable for WB, IHC-P and reacts with Mouse samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Mouse Lcn8 aa 1 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse,
Applications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Mouse Lcn8 aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q924P3

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab233510 was purified by antigen-specific affinity chromatography followed by Protein A affinity chromatography., Storage buffer-pH: 7.4Preservative: 0.011% Proclin 300Constituents: PBS, 55.77% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
LCN8 also known as Lipocalin-8 is part of the lipocalin family. It plays role mechanically in small molecule transport and storage. This protein has a molecular mass around 20 kDa. Researchers observe its expression in various tissues with significant presence in the kidney and liver. LCN8 is also known to bind and transport various small hydrophobic molecules.
Biological function summary
This protein contributes to molecule transport and cellular homeostasis. LCN8 is known to form part of a larger complex with other lipocalin family members which lets it efficiently bind and release ligands based on the cell's needs. Its activity impacts cellular metabolism by influencing the distribution of essential biomarkers and metabolites.
Pathways
LCN8 plays a significant role in lipid metabolism and signal transduction. In the lipid metabolism pathway it cooperates with proteins like LCN2 to modulate the transport of fatty acids. Similarly in signal transduction its activity can affect pathways involving lipophilic hormone signaling providing important links and modulations for cellular communication.
LCN8 has associations with metabolic disorders including obesity and diabetes. Researchers have observed altered levels of LCN8 in patients with obesity suggesting it might influence fat storage and insulin sensitivity. In diabetes its relationship with inflammation and metabolic regulation has implications for disease progression. LCN2 is another protein implicated in these disorders sharing some overlapping functions and pathways with LCN8.