Abcam, ab234248, PE Anti-CD101 antibody [BB27]

Size: 100Test
Mouse Monoclonal CD101 antibody - conjugated to PE. Suitable for Flow Cyt and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Cell preparation containing CD101 protein.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:BB27,
Isotype:IgG1,
Conjugation:PE,
Excitation/Emission:Ex: 480;565nm, Em: 578nm,
Carrier free:No,
Reacts with:Human,
Applications:Flow CytSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Cell preparation containing CD101 protein. The exact immunogen used to generate this antibody is proprietary information.Q93033

Properties and Storage Information:
Form-Liquid, Purification technique-Size-exclusion chromatography, Storage buffer-pH: 7.4Preservative: 0.0975% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
CD101 also known as IGSF2 or V7 is a transmembrane protein that weighs approximately 140 kDa. This protein is part of the immunoglobulin superfamily and is expressed on the surface of certain immune cells including dendritic cells macrophages monocytes and regulatory T cells. Researchers have also detected CD101 on some subsets of B cells. The protein has a significant role in the modulation of immune responses and functions as a marker in immune system studies.
Biological function summary
CD101 influences the immune response through its regulatory effects on cell signaling and interaction. The protein's function often centers within a complex environment contributing to the inhibitory signaling pathways that help balance immune activation. Its presence on regulatory T cells suggests a role in suppressing overactive immune responses which is important to maintaining immune homeostasis. Researchers associate CD101 expression with the control of inflammatory processes highlighting its functional significance.
Pathways
Research shows that CD101 participates in pathways key to immune regulation such as the T-cell receptor signaling pathway. This involvement connects CD101 with proteins like CD3 and CD4 emphasizing its role in modulating T-cell response. The protein plays a part in downstream signaling events that fine-tune immune responses by dampening excessive activation therefore helping prevent autoimmune reactions. It ensures the immune system effectively targets pathogens without harming host tissues.
Studies correlate CD101 expression with autoimmune diseases and inflammatory diseases including inflammatory bowel disease (IBD). These associations suggest a potential protective role of CD101 in managing chronic inflammation. Scientists have also observed interactions with proteins like TNF-alpha in these contexts reflecting the complex interplay CD101 has with pro-inflammatory cytokines. Understanding CD101's involvement in disease processes can aid in developing therapeutic strategies that aim to modulate immune responses effectively.