Abcam, ab234429, Anti-Laminin gamma 3 antibody [EPR22699-151]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal Laminin gamma 3 antibody. Suitable for WB, IHC-P, IHC-Fr, Flow Cyt (Intra) and reacts with Mouse samples. Cited in 2 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR22699-151,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse,
Applications:Flow Cyt (Intra), IHC-Fr, WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Laminin gamma 3 often referred to as lam γ3 is a subunit of the laminin protein complex which plays an important role in the structure of the extracellular matrix. Alternate names include LAMC3. This protein has a molecular mass of approximately 180 kDa and is expressed in various tissues including the skin brain and reproductive systems. Laminin gamma 3 contributes to the structural integrity and organization of the basement membrane.
Biological function summary
Laminin gamma 3 is involved in cell adhesion differentiation migration and survival. It integrates into laminin trimers forming part of the laminin-332 complex known for its role in hemidesmosome formation and epithelial cell anchorage. These interactions are critical for maintaining tissue architecture and function influencing processes such as wound healing and tissue repair.
Pathways
Laminin gamma 3 operates within pathways that regulate cell-matrix interactions and intracellular signaling. It engages in the integrin and PI3K/AKT/mTOR pathways which are critical for cellular growth and survival. Laminin gamma 3 interacts with integrins such as α3β1 and α6β4 helping to transmit signals from the extracellular matrix to the cell interior therefore influencing cell behavior and fate.
Laminin gamma 3 has been linked to conditions such as skin blistering disorders and certain forms of muscular dystrophy. In skin disorders it interacts with proteins like collagen VII highlighting its role in maintaining the structural integrity of the skin. In muscular dystrophy improper laminin gamma 3 interactions can disrupt normal muscle function contributing to disease progression.