Abcam, ab234729, Anti-SLCO1C1 antibody

Size: 100µL
Rabbit Polyclonal SLCO1C1 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Recombinant Fragment Protein within Human SLCO1C1 aa 50-350.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human SLCO1C1 aa 50-350. The exact immunogen used to generate this antibody is proprietary information.Q9NYB5

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Purification notes-Purity >95%, Storage buffer-pH: 7.4Preservative: 0.03% Proclin 300Constituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
SLCO1C1 also known as OATP1C1 is an important protein that functions as a solute carrier transporting organic ions across cell membranes. This protein has a molecular mass of approximately 76 kDa. SLCO1C1 is mainly expressed in the brain particularly in the blood-brain barrier and the choroid plexus. By mediating the passage of hormones and other molecules into the brain it plays a pivotal role in maintaining central nervous system function.
Biological function summary
This transporter facilitates the uptake of thyroid hormones such as thyroxine (T4) and triiodothyronine (T3) into the brain. Thyroid hormones are critical for brain development and function and SLCO1C1 plays a significant role in regulating their levels in the central nervous system. It does not work alone interacting with other proteins like thyroid hormone receptors to ensure proper hormone signaling in neuronal tissues.
Pathways
Thyroid hormone transport involves SLCO1C1 as well as its engagement with hormonal signaling pathways. These pathways include the regulation of metabolic processes and neural development which are essential for normal physiological function. SLCO1C1 also interacts with proteins such as MCT8 another thyroid hormone transporter integrating thyroid hormone distribution into the broader metabolic network within the brain.
Abnormal function or expression of SLCO1C1 can contribute to central nervous system disorders including neurological conditions linked to thyroid hormone imbalances like Allan-Herndon-Dudley syndrome. Research indicates that mutations or dysfunctions in SLCO1C1 along with related proteins like MCT8 could impair normal thyroid hormone transport leading to developmental and cognitive issues. Understanding SLCO1C1's role in these disorders offers possibilities for therapeutic interventions targeting thyroid hormone regulation in the brain.