Abcam, ab234798, Anti-Munc13-3 antibody

Size: 100µL
Rabbit Polyclonal Munc13-3 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human Protein unc-13 homolog C aa 400-650.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human Protein unc-13 homolog C aa 400-650. The exact immunogen used to generate this antibody is proprietary information.Q8NB66

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Purification notes-Purity >95%., Storage buffer-pH: 7.4Preservative: 0.03% Proclin 300Constituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Munc13-3 also known as Unc-13 homolog C (UNC13C) is a protein involved in synaptic vesicle priming necessary for neurotransmitter release. It weighs approximately 230 kDa. Munc13-3 is expressed mainly in the brain specifically in regions such as the cerebellum. This protein plays a role in the efficiency and timing of synaptic transmission which is critical for normal neuronal communication.
Biological function summary
Munc13-3 acts in the presynaptic region where it functions as part of the synaptic vesicle release machinery. It forms a complex with other proteins like syntaxin Munc18 and RIM proteins to facilitate neurotransmitter release. By interacting with these molecules it helps prepare vesicles for fusion with the plasma membrane modulating synaptic strength and plasticity.
Pathways
Proteins involved in synaptic transmission and plasticity often associate with Munc13-3. One important pathway is the synaptic vesicle cycle where Munc13-3 works closely with synaptotagmin and SNARE proteins to regulate vesicle docking and fusion. Another relevant pathway is the calcium signaling pathway which triggers vesicle release through Munc13-3's interactions with other calcium-sensing proteins ensuring precise neurotransmitter release in response to calcium influx.
Links between Munc13-3 and neurological conditions like autism spectrum disorders and epilepsy are evident. Munc13-3 influences synaptic function and alterations in its expression or function can disrupt normal synaptic activity. Related proteins are Munc13-1 and STXBP1 which interact with Munc13-3 in these conditions suggesting possible therapeutic targets for modulating synaptic communication issues seen in these disorders.