Abcam, ab234867, Anti-Use1 antibody

Size: 100µL
Rabbit Polyclonal USE1 antibody. Suitable for IP, WB, ICC/IF and reacts with Human, Mouse samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human USE1 aa 1-150.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:IP, WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human USE1 aa 1-150. The exact immunogen used to generate this antibody is proprietary information.Q9NZ43

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Purification notes-Purity >95%., Storage buffer-pH: 7.4Preservative: 0.03% Proclin 300Constituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Use1 also known as UNS-1 or Protein Transport Protein Use1 is involved in the SNARE-mediated transport mechanism. It has a molecular mass of approximately 29 kDa. This protein is expressed in various tissues with significant presence in the endoplasmic reticulum and Golgi apparatus. Structurally Use1 interacts with other SNARE proteins to regulate vesicle fusion processes essential for intracellular transport.
Biological function summary
Use1 plays an important role in the delivery and sorting of proteins within cells. It functions as a part of the SNARE complex which is important for the fusion of vesicles with target membranes. By ensuring the precise docking and release of vesicles this protein aids in maintaining proper cellular function. The SNARE complex including partners like Syntaxin 18 and BNIP1 ensures coordinated intracellular trafficking which is vital for cellular homeostasis.
Pathways
Use1 is deeply involved in the vesicular transport and cellular trafficking pathways. These pathways are essential for the movement of proteins and lipids between different organelles. Use1 works closely with the Golgi and endoplasmic reticulum trafficking pathways. It interacts with proteins such as Sec22b and Syntaxin 18 to facilitate vesicular transport processes. This activity ensures correct delivery of molecular cargos aiding in cellular function regulation and signal transduction.
Mutations or dysfunction of Use1 have been associated with neurodegenerative diseases and certain metabolic disorders. Neurodegenerative conditions like Alzheimer's disease show disrupted protein transport implicating Use1's role in proper neuronal function. Additionally Use1 connects with proteins like Syntaxin 5 highlighting its involvement in metabolic pathways that when altered may lead to disorders. Research continues to investigate Use1 as a potential therapeutic target for these conditions.