Abcam, ab234973, Anti-CDS2 antibody

Size: 100µL
Rabbit Polyclonal CDS2 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human CDS2 aa 350 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human CDS2 aa 350 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.O95674

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Purification notes-Purity >95%., Storage buffer-pH: 7.4Preservative: 0.03% Proclin 300Constituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
CDS2 also known as CDP-diacylglycerol synthase 2 is an enzyme that plays an important role in lipid metabolism. This protein has a molecular mass of approximately 52 kDa. It catalyzes the conversion of phosphatidic acid to CDP-diacylglycerol which is an important precursor for the synthesis of many phospholipids. CDS2 is mainly expressed in tissues with high lipid turnover such as the liver brain and adipose tissues.
Biological function summary
CDS2 is involved in maintaining cellular membrane integrity and function. It participates in the synthesis of phosphatidylinositol which is a component of the membrane and contributes to cellular signaling. CDS2 does not act alone; it functions as part of larger lipid synthesis pathways although it does not form a specific complex with other proteins. Still it interacts functionally with enzymes involved in lipid biosynthesis to ensure efficient lipid production within the cell.
Pathways
CDS2 functionally interacts in the glycerophospholipid biosynthesis and phosphatidylinositol signaling pathway. These pathways are central to generating phosphatidylinositol and related molecules which are critical for cellular processes such as membrane trafficking and signal transduction. CDS2's activity connects it with other proteins like phosphatidylinositol synthase which further modifies products of CDS2's reaction in the cell.
Abnormalities in CDS2 expression or function have correlations with metabolic disorders such as non-alcoholic fatty liver disease. Altered lipid metabolism impacts liver function where CDS2 plays an important role. Dysregulation in lipid pathways involving CDS2 may also be linked to neurological disorders given its significant expression in brain tissues. Disease associations may involve proteins such as glycerol-3-phosphate acyltransferase as their activities are interconnected in maintaining lipid homeostasis.