Abcam, ab235022, Recombinant Human AADAC/DAC protein (Tagged)

Size: 100µg
Recombinant Human AADAC/DAC protein (Tagged) is a Human Fragment protein, in the 24 to 399 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE, Mass Spec.
Key facts
Purity:>90% SDS-PAGE,
Expression system:Escherichia coli,
Tags:His tag N-Terminus,
Applications:SDS-PAGE, Mass SpecSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:No,
Accession:P22760,
Animal free:No,
Carrier free:No,
Species:Human,
Storage buffer:pH: 7.2 - 7.4Constituents: Tris buffer, 50% Glycerol (glycerin, glycerine)

Product details:
This product was previously labelled as AADAC

Properties and Storage Information:
Shipped at conditions-Blue Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
AADAC also known as arylacetamide deacetylase or DAC is an enzyme involved in the hydrolysis of ester and amide bonds. It has a molecular weight of approximately 45 kDa. This enzyme expresses largely in liver tissues and is localized in the endoplasmic reticulum membrane. AADAC catalyzes the conversion of substrates by cleaving acyl groups which is an important function for metabolic processes.
Biological function summary
AADAC plays a critical role in the metabolism of drugs and endogenous lipids. It does not form part of larger complexes but acts independently to facilitate the processing of compounds within cells. This enzymatic activity contributes to detoxification processes by altering the chemical structure of various compounds which are then excreted from the body. AADAC also influences lipid metabolism by hydrolyzing triacylglycerols which affects energy storage and utilization.
Pathways
The activity of AADAC is important in the drug metabolism pathway specifically the phase I metabolism where it interacts with different prodrugs and xenobiotics. This enzyme works closely with cytochrome P450 enzymes which are involved in further modifications of chemical substrates during metabolism. AADAC also participates in lipid metabolic pathways influencing lipid and cholesterol absorption and conversion thereby modulating energy balance.
AADAC has associations with liver diseases and drug-induced toxicities. Dysfunction or altered expression of AADAC can lead to improper drug metabolism resulting in adverse drug reactions. This enzyme is linked to liver disorders through its interaction with the cytochrome P450 family affecting the liver's capacity to process therapeutic agents. These associations make AADAC an important focus for studies on pharmacokinetics and liver health.