Abcam, ab235095, Anti-PACSIN3 antibody

Size: 100µg / 100µL
Rabbit Polyclonal PACSIN3 antibody. Suitable for WB, IHC-P and reacts with Rat, Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human Protein kinase C and casein kinase substrate in neurons protein 3 aa 1-300.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Rat, Human,
Applications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human Protein kinase C and casein kinase substrate in neurons protein 3 aa 1-300. The exact immunogen used to generate this antibody is proprietary information.Q9UKS6

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Purification notes-Purity >95%, Storage buffer-pH: 7.4Preservative: 0.03% Proclin 300Constituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
PACSIN3 also known as Protein Kinase C and Casein Kinase Substrate in Neurons Protein 3 plays a role in cellular endocytosis and cytoskeleton organization. This protein is about 47 kDa in size. You find PACSIN3 widely expressed in muscle and heart tissues. It contains an F-BAR domain allowing it to bind membranes and promote membrane curvature. This F-BAR domain is a feature of proteins involved in membrane dynamics.
Biological function summary
The role of PACSIN3 extends into various cellular processes related to membrane trafficking where it acts to modulate vesicular transport and actin reorganization. PACSIN3 interacts with other proteins to form complexes that facilitate the internalization and recycling of receptors on the cell surface. Additionally its interaction with other proteins helps regulate cytoskeletal rearrangements essential for various cellular functions.
Pathways
Functions involving PACSIN3 integrate into key signaling pathways such as the endocytic pathway and the actin polymerization pathway. Within these pathways PACSIN3 interacts with proteins like dynamin a GTPase involved in the scission of budding vesicles from the membrane. Additionally it shares functional connections with proteins such as CTTN (cortactin) another actin-binding protein that influences actin polymerization and cellular movement processes.
Several links exist between PACSIN3 and diseases associated with dysregulated endocytosis and impaired cell signaling including muscular dystrophy and heart failure. PACSIN3's relationship with dynamin which is implicated in these conditions illustrates its potential role in the progression or mitigation of these disorders. Connections between PACSIN3 and other signaling proteins such as Rho GTPases further highlight its possible involvement in these pathological states given their importance in actin cytoskeleton dynamics and membrane trafficking.