Abcam, ab235451, Anti-DPEP3 antibody [EPR21862]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal DPEP3 antibody. Suitable for IP, WB, IHC-P and reacts with Human samples. Cited in 2 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR21862,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, IHC-P, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Dipeptidase 3 (DPEP3) also known as MBD-2 or membrane-bound dipeptidase 3 is an enzyme that performs important roles in hydrolyzing dipeptides. DPEP3 has a molecular weight of approximately 52 kDa. It belongs to the dipeptidase family and is often found in the membranes of the kidney and testis where it contributes to peptide metabolism. As a metalloprotease DPEP3 requires a metal ion as a cofactor for its catalytic activity.
Biological function summary
DPEP3 contributes to diverse physiological processes in the body. This enzyme often exists as a part of a multi-protein complex facilitating the breakdown of dietary peptides and the renal processing of glutathione and leukotriene D4. Through its enzymatic action DPEP3 helps in managing extracellular matrix homeostasis and detoxifying a wide range of substances that circulate in the body.
Pathways
DPEP3 influences several metabolic pathways by engaging in the breakdown of dipeptides. Of particular note DPEP3 functions within the leukotriene metabolism and glutathione metabolism pathways. In leukotriene metabolism enzymes such as leukotriene A4 hydrolase collaborate with DPEP3 for the conversion of leukotrienes into biologically active lipid mediators. In the glutathione metabolism pathway DPEP3's activity is augmented by its interaction with glutathione S-transferases.
DPEP3 shows relevance to conditions like renal dysfunctions and allergic responses. The enzyme's role in metabolizing leukotrienes links it to asthma and other allergic conditions where dysregulated leukotriene pathways play a part. Furthermore changes in DPEP3 expression might be observed alongside alterations in the activity of glutathione S-transferases which could impact renal health and lead to disease.