Abcam, ab235626, Anti-AICL antibody [EPR22061] - BSA and Azide free

Size: 100µg / 1mg
Rabbit Recombinant Monoclonal AICL antibody. Carrier free. Suitable for IHC-P, IP, WB, ICC/IF and reacts with Human samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR22061,
Isotype:IgG,
Carrier free:Yes,
Reacts with:Human,
Applications:IHC-P, WB, ICC/IF, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
ab235626 is the carrier-free version of
ab221158
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies
Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.
Use our
conjugation kits
for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.
Compatibility
This product is compatible with the Maxpar
Antibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar
is a trademark of Fluidigm Canada Inc.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
AICL also known as activation-induced C-type lectin is a type II transmembrane protein expressed mostly on myeloid cells especially in bone marrow. It has a molecular mass of approximately 30 kDa. AICL belongs to the C-type lectin family and is often co-expressed with other members of this family on monocytes and dendritic cells. Scientists have noted that AICL appears in both the cytoplasm and on the cell surface contributing to its interaction capabilities.
Biological function summary
AICL interacts with innate immune processes and contributes to immune cell activation. It forms a complex with immune receptors such as the NK cell receptor NKG2D modulating immune responses. AICL's ligand-binding properties facilitate engagement in pathogen recognition and response enhancing the communication between innate and adaptive immunity. These interactions underline AICL's function in monitoring cellular stress and transformation.
Pathways
AICL participates significantly in the immune response through the NKG2D signaling pathway. This pathway is essential for natural killer (NK) cell-mediated cytotoxicity linking AICL closely with NK cell activation mechanisms. Additionally AICL is involved in the cytokine signaling pathway which interacts with proteins like IL-15 that are important for immune cell proliferation and function. These pathways highlight AICL's role in regulating immune surveillance and response.
AICL has significant association with leukemia and rheumatoid arthritis. In leukemia AICL expression affects the immune cell environment influencing the progression of the disease and patient prognosis. In rheumatoid arthritis altered AICL expression connects with the inflammation process where it interacts with proteins such as MICA possibly aggravating autoimmune responses. These links highlight AICL's importance in both hematological and autoimmune disorders driving interest in its potential as a diagnostic or therapeutic target.