Abcam, ab235788, Anti-TMEM71 antibody

Size: 100µL
Rabbit Polyclonal TMEM71 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human TMEM71 aa 1-250.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human TMEM71 aa 1-250. The exact immunogen used to generate this antibody is proprietary information.Q6P5X7

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Purification notes-Purity >95%., Storage buffer-pH: 7.4Preservative: 0.03% Proclin 300Constituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
TMEM71 also known as transmembrane protein 71 is an integral membrane protein with a mass of approximately 24 kDa. This protein is embedded within cellular membranes and exhibits expression across various tissues though more noticeable in the central nervous system. It contains several transmembrane domains which allow it to play a role in cellular transport and communication processes within the membrane. TMEM71's expression pattern suggests a role in maintaining cellular homeostasis.
Biological function summary
TMEM71 participates in intracellular signaling and transport processes. It does not function alone but often associates with other membrane proteins facilitating the transfer and modulation of signaling molecules across the cell membrane. Its ability to interact with different molecules points to its involvement in regulating cellular responses and maintaining equilibrium within cells.
Pathways
TMEM71's involvement spans several biological functions that include cellular signaling and transport. An important pathway it partakes in is the MAPK signaling pathway where it can interact with proteins like ERK1/2. This interaction aids in the regulation of cellular responses to external stimuli and phosphorylation events. Furthermore TMEM71 may influence calcium signaling pathways interacting with calcium-binding proteins to affect cellular contraction and neurotransmission.
TMEM71 has shown a connection to neurological disorders particularly those involving disrupted cellular signaling such as epilepsy. Abnormal expression or mutations in TMEM71 can influence the function of associated proteins such as those in the MAPK pathway which are important in neural cell communication. Additionally there is preliminary evidence linking TMEM71 to certain cancer types where its dysregulated expression might impact pathways essential for tumor progression and survival in association with proteins like MEK and RAF.