Abcam, ab236328, Recombinant Mouse SULT1A1/STP protein (Tagged)

Size: 100µg
Recombinant Mouse SULT1A1/STP protein (Tagged) is a Mouse Full Length protein, in the 1 to 291 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE, Mass Spec.
Key facts
Purity:>90% SDS-PAGE,
Expression system:Escherichia coli,
Tags:His tag N-Terminus,
Applications:SDS-PAGE, Mass SpecSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:No,
Accession:P52840,
Animal free:No,
Carrier free:No,
Species:Mouse,
Storage buffer:pH: 7.2 - 7.4Constituents: Tris buffer, 50% Glycerol (glycerin, glycerine)

Product details:
This product was previously labelled as SULT1A1

Properties and Storage Information:
Shipped at conditions-Blue Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
SULT1A1 also known as STP is an enzyme that plays an important role in the metabolism of various hormones drugs and other xenobiotic compounds. It belongs to the sulfotransferase family responsible for catalyzing the sulfate conjugation of many endogenous and exogenous compounds. SULT1A1 has a molecular mass of approximately 34 kDa. The enzyme is highly expressed in the liver but is also found in other tissues like the intestine and lung. It facilitates the transfer of a sulfo group from the universal sulfate donor 3’-phosphoadenosine-5’-phosphosulfate (PAPS) to substrates such as phenolic compounds.
Biological function summary
The enzyme contributes significantly to the detoxification and activation of its substrates in the body. SULT1A1 functions without being part of a larger protein complex allowing it direct interaction with its substrates. By modifying hormones such as estrogens and catecholamines it helps regulate their activity and half-life. Additionally SULT1A1 plays a role in the metabolic processing of drugs influencing their pharmacokinetics and pharmacodynamics.
Pathways
SULT1A1 is a critical component of both the phenolic metabolism pathway and the metabolism of xenobiotics by cytochrome P450. These pathways involve other proteins like CYP2C9 and GSTP1 which participate in further detoxification and conjugation reactions. Within these pathways SULT1A1 contributes to the inactivation or activation of compounds altering their biological activity and facilitating their excretion from the body.
SULT1A1 has been associated with variable drug responses and certain cancers. Altered activity of this enzyme can influence clearance of drugs potentially leading to adverse drug reactions or therapeutic failure. Moreover the dysregulation of estrogen metabolism partly mediated by SULT1A1 may contribute to hormone-related cancers such as breast cancer. The enzyme's interaction with proteins like UGT1A1 within these disease contexts highlights its role in the broader framework of metabolic processes impacting health and disease outcomes.