Abcam, ab236391, Anti-INPP5F antibody [OTI1D4]

Size: 100µL
Mouse Monoclonal INPP5F antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human INPP5F.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:OTI1D4,
Isotype:IgG1,
Carrier free:No,
Reacts with:Human,
Applications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Full Length Protein corresponding to Human INPP5F.Q9Y2H2

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification, Purification notes-Purified from cell culture supernatant., Storage buffer-pH: 7.3Preservative: 0.02% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
INPP5F also known as phosphatidylinositol-45-bisphosphate 5-phosphatase F functions as a lipid phosphatase that removes 5-phosphate groups from phosphoinositides. These molecules are important for cellular signaling pathways. INPP5F has a molecular mass of approximately 75 kDa. It is expressed in various tissues with higher levels found in the brain and heart. This suggests its importance in specific cellular tissues for specialized roles.
Biological function summary
Removing phosphate groups from phosphoinositides impacts cell signaling and membrane dynamics. INPP5F modulates cellular processes including cytoskeletal organization and vesicle trafficking through its phosphatase activity. It does not appear to be part of any stable complexes but regulates its substrates and influences processes through its enzymatic action.
Pathways
INPP5F participates in important signaling pathways such as the phosphatidylinositol signaling system and the PI3K-Akt pathway. These pathways are essential for controlling cell growth and survival. INPP5F is functionally related to other phosphatases including PTEN which also act within these pathways to balance signaling activities for normal cellular function.
INPP5F has been linked to cardiovascular diseases and certain neurodegenerative disorders. Disturbances in its activity can result in altered signaling impacting heart function and brain health. It connects to proteins like Akt through the PI3K pathway in cardiovascular contexts whereas disruptions may influence Alzheimer's disease pathology by affecting cellular signaling and regulation.