Abcam, ab236392, Anti-IRF2BP1 antibody [OTI3A6]

Size: 100µL
Mouse Monoclonal IRF2BP1 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human IRF2BP1 aa 450 to C-terminus.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:OTI3A6,
Isotype:IgG2b,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human IRF2BP1 aa 450 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q8IU81

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification, Purification notes-Purified from cell culture supernatant., Storage buffer-pH: 7.3Preservative: 0.02% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
IRF2BP1 also known as Interferon Regulatory Factor 2 Binding Protein 1 is a protein involved in regulating gene expression. It has a molecular mass of approximately 64 kDa. This protein plays a role as a transcriptional corepressor meaning it helps repress the activity of certain genes. IRF2BP1 is expressed in various tissues with notable expression in immune cells which suggests its involvement in immune system regulation.
Biological function summary
IRF2BP1 interacts with other proteins to modulate transcriptional repression. It forms part of a complex that includes other co-repressors which collaborate to regulate gene expression tightly. One of its main functions is to inhibit the activity of IRF2 an important transcription factor involved in innate immunity. This inhibition allows for fine-tuning of the immune response and helps maintain immune homeostasis.
Pathways
IRF2BP1 functions within the interferon signaling pathway playing a regulatory role by modulating IRF2 activity. This pathway is important for responding to viral infections and other immune challenges. By interacting with IRF2 IRF2BP1 controls gene expression related to immune response. Additionally IRF2BP1 is involved in pathways related to transcriptional regulation where it may impact the expression of genes under specific conditions.
IRF2BP1 has associations with autoimmune diseases and cancer. Its role in repressing IRF2 suggests that dysregulation could lead to imbalances in the immune response potentially contributing to conditions like systemic lupus erythematosus. Furthermore its activity links to cancer where aberrant expression or function might result in disrupted cell growth and apoptosis. In these contexts IRF1 another immune regulatory protein may interact with IRF2BP1 impacting the outcomes related to such diseases.