Abcam, ab236393, Anti-Kv beta 1/KCNAB1 antibody [OTI9F7]

Size: 100µL
Mouse Monoclonal Kv beta 1/KCNAB1 antibody. Suitable for IHC-P, WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human KCNAB1.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:OTI9F7,
Isotype:IgG1,
Carrier free:No,
Reacts with:Human,
Applications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Full Length Protein corresponding to Human KCNAB1.Q14722

Product details:
Clone OTI9F7 (formerly 9F7).

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification, Purification notes-Purified from cell culture supernatant., Storage buffer-pH: 7.3Preservative: 0.02% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Kv beta 1 also known as KCNAB1 is an auxiliary subunit of voltage-gated potassium channels. This protein modulates the functional properties of the Kv channel complex. Kv beta 1 possesses a molecular mass of approximately 44 kDa. It is expressed extensively in the brain and heart where it plays an important role in regulating electrical excitability. By binding to the alpha subunit of the potassium channel Kv beta 1 affects the channel's inactivation dynamics influencing the flow of potassium ions across cell membranes.
Biological function summary
Kv beta 1/KCNAB1 functions as a regulatory component of the Kv channel complex. It interacts with the channel alpha subunits to modify gating properties channel kinetics and response to cellular signals. Kv beta 1 enhances rapid inactivation of certain Kv channels affecting nerve impulse transmission and cardiac muscle contraction. This regulation is essential for maintaining proper action potential shapes and frequencies ensuring appropriate electrical signaling in neurons and cardiac cells.
Pathways
Kv beta 1 is importantly integrated into electrical signaling pathways related to neuronal excitability and cardiac electrical cycle. It is significantly involved in the regulation of the action potential propagation in neurons and myocytes. Kv beta 1 prominently interacts with Kv alpha subunits like Kv1.1 and Kv1.2 affecting their physiological roles and contributing to finely-tuned ion homeostasis during prolonged cellular activities.
Altered Kv beta 1 function associates with certain neurological and cardiac conditions. Dysregulation of this protein's activity links to epilepsy where abnormal neuronal excitability occurs. It is also implicated in cardiac arrhythmias due to its role in cardiac repolarization. Relationships with proteins such as Kv1.1 and Kv1.2 are evident in these conditions suggesting that therapeutic targeting of Kv beta 1 might offer potential benefits in managing these disorders.