Abcam, ab236402, Anti-OBFC2A antibody [OTI6B10]

Size: 100µL
Mouse Monoclonal OBFC2A antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human NABP1.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:OTI6B10,
Isotype:IgG2b,
Carrier free:No,
Reacts with:Human,
Applications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Full Length Protein corresponding to Human NABP1.Q96AH0

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification, Purification notes-Purified from cell culture supernatant by affinity chromatography., Storage buffer-pH: 7.3Preservative: 0.02% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
OBFC2A also known as hSSB2 is a single-stranded DNA-binding protein with a molecular mass of approximately 29 kDa. It expresses in several tissues including the brain heart and skeletal muscle. OBFC2A plays a role in protecting single-stranded DNA regions during DNA replication and repair. By binding to single-stranded DNA OBFC2A prevents unwanted DNA degradation and assists in maintaining genome stability.
Biological function summary
OBFC2A participates in DNA replication and repair processes. It forms part of the telomere maintenance complex where its function ensures effective telomere replication and elongation. This involvement helps preserve chromosomal integrity. By working within this complex OBFC2A contributes to the overall stability and maintenance of genetic information during cell division.
Pathways
OBFC2A is important in telomere maintenance and the DNA damage response pathways. In the telomere maintenance pathway OBFC2A interacts with proteins like POT1 and TPP1 which are part of the shelterin complex ensuring proper telomeric function. In the DNA damage response pathway OBFC2A works alongside proteins such as ATR contributing to the recognition and repair of damaged DNA signaling the appropriate cellular responses to maintain genetic fidelity.
OBFC2A has associations with cancer and telomere-related disorders. Its involvement in maintaining telomere integrity makes it relevant in cancer progression as mutations or dysregulation in OBFC2A could potentially lead to genomic instability and tumorigenesis. Furthermore its interaction with proteins like POT1 connects it to hereditary disorders such as dyskeratosis congenita where telomere maintenance is compromised resulting in premature cell aging and related pathologies.