Abcam, ab236419, Anti-TAPBP-R antibody [OTI1C9]

Size: 100µL
Mouse Monoclonal TAPBP-R antibody. Suitable for IHC-P, WB and reacts with Human, Mouse, African green monkey samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human TAPBPL.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:OTI1C9,
Isotype:IgG1,
Carrier free:No,
Reacts with:Mouse, Human, African green monkey,
Applications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Full Length Protein corresponding to Human TAPBPL.Q9BX59

Product details:
Clone OTI1C9 (formerly 1C9).

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification, Purification notes-Purified from cell culture supernatant., Storage buffer-pH: 7.3Preservative: 0.02% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
TAPBP-R also known as Tapasin-related protein is a protein that mechanically facilitates immune function by assisting in the assembly and stabilization of the major histocompatibility complex (MHC) Class I molecules. It weighs approximately 46 kDa. TAPBP-R is expressed widely across various tissues with notable presence in the thymus and lymph nodes. It plays a significant role in immune surveillance and the presentation of antigenic peptides.
Biological function summary
TAPBP-R interacts in the peptide loading complex which supports the proper folding and peptide binding to MHC Class I molecules. This interaction allows effective antigen presentation necessary for the immune response. TAPBP-R works alongside other components of the peptide loading complex including TAP1 and TAP2 transporters calnexin and ERp57 contributing significantly to immune function.
Pathways
TAPBP-R operates within the antigen processing and presentation pathway. This protein aligns closely with the MHC Class I antigen presentation pathway where TAP1 and TAP2 are essential partners. Within this system TAPBP-R optimizes MHC Class I assembly coordinating with key pathway proteins to maintain efficient immune surveillance and responses against pathogens.
TAPBP-R links with conditions such as autoimmune diseases and cancer. Abnormalities in TAPBP-R expression or function can disrupt antigen presentation influencing the progression of autoimmune disorders. Additionally TAPBP-R connects with proteins like MHC Class I in cancer where its modified expression might facilitate immune evasion by tumor cells. Understanding these interactions provides insights into therapeutic targets and immune modulation in such diseases.