Abcam, ab236428, Anti-ZNF558 antibody [OTI2C4]

Size: 100µL
Mouse Monoclonal ZNF558 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human Zinc finger protein 558.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:OTI2C4,
Isotype:IgG2b,
Carrier free:No,
Reacts with:Human,
Applications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Full Length Protein corresponding to Human Zinc finger protein 558.Q96NG5

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification, Purification notes-Purified from cell culture supernatant., Storage buffer-pH: 7.3Preservative: 0.02% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ZNF558 also known as Zinc Finger Protein 558 functions as a transcription factor with a mass of approximately 88 kDa. It contains a series of zinc finger motifs that enable it to bind DNA thereby regulating gene expression. ZNF558 sees expression in various tissues including the brain and immune system. Through its action it influences transcriptional activity and affects downstream gene regulation which can modify cellular processes.
Biological function summary
The role of ZNF558 involves controlling the expression of genes related to cellular growth and differentiation. It acts dynamically within specific gene-regulatory networks rather than being part of a stable protein complex. The biological impact of ZNF558 on cellular processes indicates its importance in maintaining cellular homeostasis. Its function in developmental pathways suggests that it interacts with other zinc finger proteins to fine-tune gene expression responses to environmental and cellular conditions.
Pathways
ZNF558 participates in the transcription regulatory network. It plays a part in the Wnt signaling pathway influencing important cellular responses such as proliferation and differentiation. Through this pathway ZNF558 interacts with other proteins like β-catenin which furthers the signal transduction to drive transcriptional outcomes. Additionally the protein links with the Notch signaling pathway which can affect gene expression diversity.
Aberrant expression or mutations of ZNF558 associate with certain cancers and neurological disorders. In some cancer types altered levels of ZNF558 can affect cell cycle control by interacting with tumor suppressor proteins leading to uncontrollable cell proliferation. On the neurological front its irregular function potentially contributes to disorders involving neurodevelopment alongside proteins like REST which regulate neuronal gene expression and are significant for proper neuronal functions.