Abcam, ab236491, Anti-HLA B7 antibody [CATA-1]

Size: 100µg
Mouse Monoclonal HLA B antibody. Suitable for IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Cell preparation containing HLA-B protein.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:CATA-1,
Isotype:IgG2a,
Light chain type:kappa,
Carrier free:No,
Reacts with:Human,
Applications:IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Cell preparation containing HLA-B protein. The exact immunogen used to generate this antibody is proprietary information.P01889

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A/G, Purification notes-Purified from bioreactor concentrate by Protein A/G., Storage buffer-pH: 7.2 - 7.4Preservative: 0.05% Sodium azideConstituents: PBS, 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
HLA-B7 also known as HL-A B7 is a part of the human leukocyte antigen (HLA) system and belongs to the HLA class I heavy chain paralogs. This protein has a molecular mass of approximately 45 kDa. HLA-B7 is expressed on the surface of nearly all nucleated cells in the body. Its main role is to present peptide antigens to the immune system specifically to cytotoxic T cells which play an important part in immune response.
Biological function summary
HLA-B7 is involved in antigen presentation as a part of the major histocompatibility complex (MHC) class I molecule. HLA-B7 like other HLA class I molecules presents endogenous peptides to CD8+ T cells. The HLA B27 pair although different from HLA-B7 shares functional similarities that influence immune surveillance and activation processes.
Pathways
HLA-B7 participates in the antigen processing and presentation pathway. This pathway allows the presentation of intracellularly derived peptides at the cell surface which are recognized by T cell receptors (TCR) on CD8+ T lymphocytes. HLA-B7 works in concert with proteasomes for peptide generation and with transporter associated with antigen processing (TAP) for delivering peptides to the endoplasmic reticulum.
HLA-B7 is linked with certain autoimmune diseases and viral infections. Some studies suggest an association with increased susceptibility to diseases such as sarcoidosis. Moreover individuals who are HLA-B7 positive may differ in their immune response to viral infections like HIV. The interaction between HLA-B7 and proteins like beta-2 microglobulin further affects its role in disease mechanisms and immune function.