Abcam, ab236493, Anti-Insulin Receptor alpha antibody [INSR/2277R]

Size: 100µg
Rabbit Recombinant Monoclonal Insulin Receptor antibody. Suitable for IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human INSR.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:INSR/2277R,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human INSR. The exact immunogen used to generate this antibody is proprietary information.P06213

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A/G, Purification notes-Purified from bioreactor concentrate by Protein A/G., Storage buffer-pH: 7.2 - 7.4Preservative: 0.05% Sodium azideConstituents: PBS, 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The Insulin Receptor alpha (INSTA) sometimes called Insulin Receptor Subunit alpha is an integral component of the insulin receptor complex. It is an important site for insulin binding and exhibits a molecular weight (MW) of approximately 157 kDa. The receptor commonly distributes on the surface of cells with high expression in muscle cells liver cells and adipose tissue. Insulin receptor antibodies can target this protein for various studies including Western blot analyses. The protein structure itself comprises two alpha subunits alongside two beta subunits which together facilitate insulin's physiological effects.
Biological function summary
INSTA plays a critical role in glucose uptake and regulation of energy metabolism. It is an extracellular receptor involved in the formation of a tetrameric complex when interacting with insulin triggering downstream signaling cascades. The receptor helps mediate processes including glycogen synthesis lipid metabolism and protein synthesis through its influence on glucose transport and metabolic enzyme activity. The interaction with insulin generates a conformational change in the receptor which propagates cellular signal transduction essential for metabolic homeostasis.
Pathways
INSTA forms part of the insulin signaling pathway and the PI3K/Akt pathway. These pathways are essential for cellular glucose uptake and ensure energy balance within the body. Insulin receptor interacts with proteins like IRS-1 and PI3K which play roles in mediating insulin's effects. As part of these pathways INSTA assists in the convergence of signals that regulate anabolic and catabolic processes within cells making it integral to maintaining normal metabolic functions.
INSTA holds a significant connection to conditions such as type 2 diabetes mellitus and insulin resistance. Both linked to misregulation or dysregulation of insulin receptor functions these disorders underline the importance of the insulin receptor in maintaining glucose homeostasis within the body. Moreover INSTA's association with other proteins such as IRS-1 becomes particularly apparent in these disease states as malfunctioning of these proteins can impair the insulin signaling cascade exacerbating metabolic syndrome. Understanding INSTA's role provides insight into therapeutic targets for managing these related conditions.