Abcam, ab236615, Anti-ethanolamine kinase antibody

Size: 100µL
Rabbit Polyclonal ethanolamine kinase antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human ETNK1 aa 50-300.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human ETNK1 aa 50-300. The exact immunogen used to generate this antibody is proprietary information.Q9HBU6

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Purification notes-Purity >95%., Storage buffer-pH: 7.4Preservative: 0.03% Proclin 300Constituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Ethanolamine kinase often referred to as ETNK1 is an enzyme known for its role in phospholipid metabolism. It catalyzes the phosphorylation of ethanolamine to produce phosphoethanolamine. This enzyme has a molecular weight of approximately 45 kDa. Ethanolamine kinase is expressed in various tissues including liver and brain indicating its importance in systemic metabolic processes.
Biological function summary
The enzyme is involved in the Kennedy pathway which is responsible for the biosynthesis of phosphatidylethanolamine an important membrane lipid. Ethanolamine kinase operates independently and is not part of any larger protein complex. It supports cellular functions including membrane formation and repair which are critical for proper cell function and signaling.
Pathways
Ethanolamine kinase plays a significant role in the phospholipid biosynthesis pathway and the related glycerophospholipid metabolism pathway. In these pathways it interacts with other enzymes like CTP:phosphoethanolamine cytidylyltransferase shaping the production and regulation of membrane phospholipids. These pathways are essential for maintaining cellular membrane integrity and fluidity.
Ethanolamine kinase has been linked to neurological disorders. Abnormalities in its function can lead to issues in brain phospholipid metabolism potentially contributing to conditions like Alzheimer's disease. Additionally alterations in ethanolamine kinase expression or activity might impact proteins involved in neurodegenerative processes further influencing disease progression.