Abcam, ab236618, Anti-Gas1 antibody

Size: 100µL
Rabbit Polyclonal GAS1 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Human samples. Cited in 5 publications. Immunogen corresponding to Recombinant Fragment Protein within Human Growth arrest-specific protein 1 aa 200 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human Growth arrest-specific protein 1 aa 200 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.P54826

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Purification notes-Purity >95%, Storage buffer-pH: 7.4Preservative: 0.03% Proclin 300Constituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The growth arrest-specific 1 protein or Gas1 plays an inhibitory role in cell cycle progression by interacting with various growth factors and receptors. Gas1 often termed as Gas-1 is a 38 kDa protein. It expresses prominently in quiescent cells particularly in the nervous and embryonic tissues. This expression helps control the proliferation of cells which is critical for maintaining normal cellular functions and structure.
Biological function summary
Gas1 acts as a negative regulator of cell proliferation particularly during developmental processes. It is not part of a complex but serves as a standalone inhibitor that influences cell growth. The protein interacts with components like Hedgehog signaling which leads to its involvement in developmental signaling pathways. Gas1's role in growth arrest demonstrates its importance in controlling the balance of cellular differentiation and proliferation.
Pathways
Gas1 significantly influences the Hedgehog signaling pathway and the G1 phase of the cell cycle. In the Hedgehog pathway Gas1 interacts with other key proteins like Patched and Smoothened regulating the pathway's activity which is essential for embryonic development and tissue patterning. Its interaction with these proteins highlights its regulatory function in signal transduction influencing how cells respond to growth cues.
Gas1's dysregulation links to cancer and congenital malformations. Such disorders often occur due to alterations in the Hedgehog signaling pathway implicating Gas1 as a contributor in aberrant cell growth conditions. In cancer specifically Gas1 may influence tumor suppression mechanisms impacting cells' growth arrest. Mutations in components of the Hedgehog pathway such as Smoothened can alter Gas1's function giving rise to developmental disorders and cancer progression.