Abcam, ab236621, Anti-AGPS antibody

Size: 100µL
Rabbit Polyclonal AGPS antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Human, Mouse samples. Cited in 6 publications. Immunogen corresponding to Recombinant Fragment Protein within Human AGPS aa 250-400.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:WB, ICC/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human AGPS aa 250-400. The exact immunogen used to generate this antibody is proprietary information.O00116

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Purification notes-Purity >95%, Storage buffer-pH: 7.4Preservative: 0.03% Proclin 300Constituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
AGPS also known as alkylglycerone phosphate synthase represents an important enzyme in lipid metabolism with a molecular mass of approximately 73 kDa. It catalyzes the formation of alkylglycerone phosphate from dihydroxyacetone phosphate and fatty alcohols a reaction that occurs in peroxisomes. AGPS is expressed in various tissues with high levels observed in the brain heart and reproductive organs. Its expression is important for proper plasmalogen synthesis an essential lipid component of cell membranes.
Biological function summary
AGPS functions as an important component in the synthesis of ether lipids specifically plasmalogens which play a role in membrane structure and signaling. Plasmalogens are phospholipids that are part of cellular membranes and influence membrane fluidity and dynamics. AGPS operates as a sole enzyme in the initial step of de novo plasmalogen biosynthesis engaging with other enzymes to complete this lipid complex. Its activity ensures the proper formation of plasmalogens which are particularly abundant in the heart and nervous tissues.
Pathways
AGPS plays a central role in the ether lipid biosynthesis pathway and interacts with proteins involved in lipid metabolism. Plasmalogen biosynthesis is a critical pathway where AGPS catalyzes the first step acting as a precursor in the synthesis of several ether lipids. Within the biosynthetic pathway AGPS works alongside enzymes such as fatty acyl-CoA reductase highlighting its collaboration with other proteins to regulate lipid homeostasis in cellular membranes.
Defects in AGPS can relate to conditions such as rhizomelic chondrodysplasia punctata (RCDP) and Zellweger spectrum disorders. RCDP presents severe skeletal malformations among other symptoms while Zellweger disorders involve multiple organ dysfunctions due to peroxisomal biogenesis issues. Mutations in AGPS often result in developmental delays and neurological impairment. Additionally AGPS dysfunction affects proteins like PEX7 which is important for targeting peroxisomal enzymes further exacerbating the disease phenotypes associated with these conditions.