Abcam, ab236629, Anti-PSRC2 antibody [EPR20913-32]

Size: 20µL / 100µL / 1mL
Rabbit Recombinant Monoclonal zfc3h1 antibody. Suitable for WB and reacts with Mouse, Rat, Human samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR20913-32,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
PSRC2 also known as Proline/Serine-rich Coiled-coil 2 is a protein with a known mass of approximately 28 kDa. This protein is expressed in a variety of tissues with notable presence in the brain and testis. Mechanically PSRC2 participates in cellular processes through its role in cytoskeleton organization. It exhibits specific binding properties which facilitate its involvement in microtubule dynamics aiding in the stabilization or destabilization of these structures during cell division.
Biological function summary
The coordination within microtubule dynamics which PSRC2 involves itself can significantly influence cellular mitosis and overall cell cycle progression. PSRC2 may also act as part of a larger protein complex contributing to the efficient alignment and separation of chromosomes during mitotic spindle formation. This functionality highlights its pivotal role in ensuring accurate cell division and genomic stability.
Pathways
The microtubule regulatory functions of PSRC2 integrate it within the cellular cytoskeleton organization pathways. It connects closely with the mitotic spindle checkpoint pathway working alongside other proteins such as tubulins and members of the Aurora kinase family. PSRC2's role supports the fidelity of cell cycle transitions ensuring that spindle assembly and chromosome segregation proceed without interruption.
Disruptions in the function of PSRC2 can have implications for cancer progression particularly where abnormal cell division characterizes tumor growth. Aberrations in PSRC2 expression levels or its interaction network with proteins like Aurora kinases may correlate with tumorigenesis. Additionally it holds a potential link with neurodegenerative conditions given its expression in the brain where defective microtubule functions could lead to neuropathologies.