Abcam, ab236889, Anti-COX6A1 antibody

Size: 100µL
Rabbit Polyclonal COX6A1 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Human, Mouse samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human COX6A1.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:IHC-P, ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Full Length Protein corresponding to Human COX6A1.P12074

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Purification notes-Purity >95%., Storage buffer-pH: 7.4Preservative: 0.03% Proclin 300Constituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
COX6A1 also known as Cytochrome c oxidase subunit 6A1 plays an important role in the electron transport chain by being part of the cytochrome c oxidase (complex IV) in mitochondria. This subunit has a mass of approximately 14 kDa. COX6A1 expresses in various human tissues but shows higher expression in tissues with significant energy demands such as the heart and skeletal muscle. This evidence suggests its critical involvement in cellular energy production.
Biological function summary
COX6A1 contributes to the formation of the cytochrome c oxidase complex which is the terminal enzyme in the mitochondrial respiratory chain. This complex facilitates the transfer of electrons from cytochrome c to oxygen leading to ATP production through oxidative phosphorylation. COX6A1 is an integral component of this complex which exists as part of the inner mitochondrial membrane. It interacts with other subunits to ensure efficient electron transfer and energy conversion.
Pathways
COX6A1 heavily influences the mitochondrial respiratory pathway particularly in oxidative phosphorylation. This pathway includes important components like NADH: ubiquinone oxidoreductase and cytochrome c. COX6A1 bridges interactions within the complex IV with proteins such as COX1 enabling proper electron transport and proton pumping necessary for ATP synthesis. Dysfunction in these interactions may affect overall cellular respiration efficiency.
Mutations and dysregulation of COX6A1 relate to various mitochondrial disorders and neurodegenerative conditions such as Leigh syndrome. Its interactions with other mitochondrial proteins like COX2 and COX3 are vital for maintaining mitochondrial function. Deficiencies in COX6A1 can disrupt proper electron transport leading to decreased ATP production and contributing to pathology in energy-demanding tissues like the brain and muscles.