Abcam, ab236933, Recombinant Staphylococcus aureus Exfoliative Toxin A/ETA protein (His tag)

Size: 100µg
Recombinant Staphylococcus aureus Exfoliative Toxin A/ETA protein (His tag) is a Staphylococcus aureus Full Length protein, in the 39 to 280 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE, Mass Spec.
Key facts
Purity:>90% SDS-PAGE,
Expression system:Escherichia coli,
Tags:His tag N-Terminus,
Applications:SDS-PAGE, Mass SpecSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:No,
Accession:P09331,
Animal free:No,
Carrier free:No,
Species:Staphylococcus aureus,
Storage buffer:pH: 7.2 - 7.4Constituents: 50% Glycerol (glycerin, glycerine), 43.5% Sodium chloride, 5% Tris HCl, 1.5% Staphylococcus aureus Exfoliative Toxin A/ETA protein

Product details:
This product was previously labelled as Exfoliative Toxin A

Properties and Storage Information:
Shipped at conditions-Blue Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Exfoliative Toxin A often referred to as ETA or exfoliative toxins is a powerful bacterial protease. Its molecular mass is approximately 27 kDa. Exfoliative Toxin A is expressed by Staphylococcus aureus particularly strains involved in skin infections. This toxin is known for cleaving desmoglein-1 a calcium-dependent cell adhesion molecule in the skin leading to epidermal detachment.
Biological function summary
Exfoliative toxins threaten the integrity of the skin barrier by targeting desmoglein-1 which compromises cellular adhesion within the epidermis. This specific action does not associate Exfoliative Toxin A with any larger protein complexes but rather with specialized pathways directly targeting epidermal cohesion. The cleavage of desmoglein-1 by ETA is significant in the pathogenic strategies of Staphylococcus aureus to cause skin exfoliation.
Pathways
Activities of Exfoliative Toxin A are integral to the pathogenesis of skin exfoliative conditions through the epidermal-dermal disruption pathway. This toxin associates with the serine protease family which modulates proteolytic pathways responsible for tissue damage and inflammation. Its action reverberates through pathways that involve proteins like desmoglein-1 emphasizing the complexity of cellular adhesion and skin integrity pathways.
Exfoliative toxin A exhibits a strong correlation with Staphylococcal Scalded Skin Syndrome (SSSS) and impetigo. These conditions are notable for their disruption of skin architecture and extensive blistering. Exfoliative Toxin A's interaction with desmoglein-1 plays a pivotal role in the pathophysiology of these diseases leading to significant epidermal peeling and vulnerability to secondary infections.