Abcam, ab236970, Anti-GPR176 antibody

Size: 100µL
Rabbit Polyclonal GPR176 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human GPR176 aa 300 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human GPR176 aa 300 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q14439

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Purification notes-Purity >95%, Storage buffer-pH: 7.4Preservative: 0.03% Proclin 300Constituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
GPR176 also known as G protein-coupled receptor 176 is a member of the G protein-coupled receptor family. The receptor has a molecular mass of around 47 kDa. Usually you find it expressed in various tissues including the brain and lymphoid organs. As a GPCR GPR176 may act through activating specific G proteins that transmit signals inside cells leading to various cellular responses.
Biological function summary
GPR176 shows roles in regulating circadian rhythms and immune system functions. It appears not to form a complex but influences biological processes through its signaling pathways. Evidence suggests that it modulates certain aspects of the immune response by impacting the behavior of immune cells.
Pathways
GPR176 participates in pathways connected to the regulation of circadian rhythms and immune system signaling. It interacts with pathways involving other GPCRs which are critical for maintaining physiological homeostasis. Proteins such as CLOCK and PER1 in the circadian rhythm pathway are related to the actions of GPR176 helping coordinate daily physiological cycles.
Researchers link GPR176 to conditions like immune dysfunction and mood disorders. In particular dysregulation of circadian rhythms can have ties with mood disorders where GPR176 plays a role. The target also shows relevance to immune-related conditions interconnected with proteins like NF-kB which influence inflammation and immune responses.