Abcam, ab236975, Anti-ICB1 antibody

Size: 100µL
Rabbit Polyclonal ICB1 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Human, Mouse samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human THEMIS2 aa 50-200.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:ICC/IF, WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human THEMIS2 aa 50-200. The exact immunogen used to generate this antibody is proprietary information.Q5TEJ8

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Purification notes-Purity >95%., Storage buffer-pH: 7.4Preservative: 0.03% Proclin 300Constituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The protein ICB1 also known as Intermediate Complex B1 exhibits mechanical functions critical to cellular processes. With a molecular mass of approximately 50 kDa ICB1 is widely expressed in various tissues including the liver brain and muscles. This protein contributes to important mechanistic roles in cells influencing their structural and functional stability. Its distribution across different tissues indicates its involvement in diverse cellular functions.
Biological function summary
The role of ICB1 is linked to cellular signaling pathways and structural maintenance. It often forms part of a larger protein complex within the cytoplasm contributing to cytoskeletal integrity. Through its interactions ICB1 helps in the regulation of intracellular transport and communication. Its integration into multiprotein complexes highlights its importance in maintaining cellular architecture and communication networks.
Pathways
ICB1 participates in signaling cascades such as the MAPK and PI3K-Akt pathways. These pathways are essential for cell survival growth and differentiation. ICB1 interacts with proteins like Akt and ERK1/2 helping to mediate signals that influence cell fate decisions. Its role in these pathways highlights its importance in regulating cell proliferation and responses to external stimuli.
ICB1 has connections to neurodegenerative diseases and certain cancers. In Alzheimer's disease ICB1 is thought to influence the pathology through its interaction with tau proteins contributing to neurofibrillary tangle formation. In some types of cancer alterations in ICB1 expression affect cell cycle regulation promoting unrestrained growth. Understanding the involvement of ICB1 with proteins like tau and cyclin-dependent kinases in these contexts is important for therapeutic development.