Abcam, ab236977, Anti-MOV10L1/Champ antibody

Size: 100µL
Rabbit Polyclonal MOV10L1/Champ antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human RNA helicase Mov10l1 aa 300-450.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human RNA helicase Mov10l1 aa 300-450. The exact immunogen used to generate this antibody is proprietary information.Q9BXT6

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Purification notes-Purity >95%., Storage buffer-pH: 7.4Preservative: 0.03% Proclin 300Constituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
MOV10L1 also known as Champ is a protein that acts as a RNA helicase with well-characterized unwinding properties. It has an approximate molecular mass of 130 kDa. MOV10L1 is expressed prominently in the testis specifically in germ cells during spermatogenesis. The expression of this protein is regulated tightly indicating its involvement in specific cellular processes related to fertility.
Biological function summary
MOV10L1 participates actively in the piRNA pathway which plays a role in silencing transposable elements in the germline. It forms part of complexes with Piwi proteins which are essential for the maturation of piRNAs and the maintenance of genome integrity in the germ cells. MOV10L1 ensures proper germ cell development by governing piRNA biogenesis. This process indicates its importance in protecting the genetic material from potential transposon-induced damage.
Pathways
MOV10L1 integrates into the piRNA metabolic pathway a vital part of post-transcriptional gene regulation. Piwi-interacting proteins such as PIWIL1 and PIWIL2 work tightly alongside MOV10L1. In this pathway MOV10L1 assists in the stabilization and processing of piRNAs therefore ensuring effective silencing of transposable elements. This function places MOV10L1 at a critical junction of gene regulation and genome safeguarding during germ cell differentiation.
MOV10L1 is implicated notably in infertility due to its role in spermatogenesis. Deficiency or dysfunction of MOV10L1 links to spermatogenic failure resulting in compromised male fertility. Furthermore connections between MOV10L1 and factors like DAZL and MVH both related to germ cell function further highlight its relevance in reproductive health. Understanding the disruptions in MOV10L1 function can lead to insights into certain infertility disorders potentially guiding therapeutic avenues.