Abcam, ab237048, Anti-TTI2 antibody

Size: 100µL
Rabbit Polyclonal TTI2 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Rat, Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human TTI2 aa 150-300.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Rat, Human,
Applications:ICC/IF, IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human TTI2 aa 150-300. The exact immunogen used to generate this antibody is proprietary information.Q6NXR4

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Purification notes-Purity >95%, Storage buffer-pH: 7.4Preservative: 0.03% Proclin 300Constituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
TTI2 also known as TELO2 interacting protein 2 is a protein with a molecular mass of approximately 56 kDa. It plays a mechanical role as part of the TTT complex which also includes TELO2 and TTI1. TTI2 is essential for the stability and maturation of the phosphoinositide 3-kinase-related kinase (PIKK) family. It is mostly expressed in human tissues with significant levels in heart brain and liver. Researchers study TTI2 because of its involvement in cellular processes that ensure the cell responds effectively to stress and repair mechanisms.
Biological function summary
TTI2 acts as a stabilizing factor within the TTT complex providing structural support required for maturation and stabilization of PIKKs. This complex is important for protein folding and quality control within cells. TTI2 facilitates protein-protein interactions necessary for the assembly of functional PIKK complexes like ATM and mTOR which regulate cellular responses to DNA damage and nutrient signals. Through these functions TTI2 influences cell cycle regulation and growth.
Pathways
TTI2 contributes significantly to the DNA damage response and mTOR signaling pathways. In the DNA damage response pathway its role within the TTT complex supports the activity of ATM protein an important kinase involved in repairing damaged DNA. In the mTOR signaling pathway TTI2 assists in the regulation of metabolism and growth acting in concert with other components of the TTT complex to maintain proper cell function and survival. This interaction connects TTI2 to various proteins like TTI1 and TELO2 reinforcing its importance within these pathways.
TTI2 has associations with cancer and neurological disorders. Dysregulation of TTI2 may impact the stability of PIKKs leading to impaired DNA damage response which can contribute to cancer development. Additionally limited TTI2 function has links to neurodegenerative diseases due to its role in maintaining neuronal cell health through mTOR signaling. The protein's interactions with ATM in cancer and mTOR in neurological disorders underline its relevance to these conditions connecting TTI2 to broader pathways that when disrupted lead to disease.