Abcam, ab23705, Anti-phospholipase A2 antibody

Size: 100µL
Rabbit Polyclonal Phospholipase A2 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 25 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human PLA2G2A.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Full Length Protein corresponding to Human PLA2G2A.P14555

Properties and Storage Information:
Form-Liquid, Purity-Whole antiserum, Storage buffer-Constituents: Whole serum, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Phospholipase A2 (PLA2) is an enzyme that hydrolyzes the sn-2 ester bond of phospholipids releasing fatty acids and lysophospholipids. This process is essential for producing pro-inflammatory eicosanoids and other lipid mediators. Commonly known as PLA2 or phospholipase its molecular mass varies depending on its type ranging from 14 to 45 kDa. PLA2 is expressed in many tissues including the pancreas brain and immune cells highlighting its diverse role in different physiological contexts.
Biological function summary
Phospholipase A2 contributes to membrane remodeling and the release of arachidonic acid a precursor to prostaglandins and leukotrienes vital for inflammatory responses. It often functions as part of a complex with other proteins that regulate its activity ensuring precise lipid signaling and homeostasis. Understanding PLA2 function leads to insights into cell signaling and inflammatory regulation.
Pathways
Phospholipase A2 plays a significant role in the arachidonic acid pathway and is involved in the production of eicosanoids. These pathways are important for the inflammatory response and involve interactions with cyclooxygenases (COX) and lipoxygenases (LOX). Through these pathways PLA2 activity can influence immune responses and cellular metabolism making it an important component in inflammatory signaling cascades.
Phospholipase A2 is implicated in conditions like arthritis and atherosclerosis. Its role in inflammation makes it a potential target for therapeutic interventions. PLA2 interacts with proteins such as COX-2 which are involved in the inflammatory response in arthritis while its role in lipid metabolism links it to the formation of atherosclerotic plaques. Understanding these connections can aid in developing treatments for inflammatory and cardiovascular diseases.