Abcam, ab237055, Anti-Pannexin 3 antibody

Size: 100µL
Rabbit Polyclonal Pannexin 3 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human Pannexin-3 aa 100-250.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human Pannexin-3 aa 100-250. The exact immunogen used to generate this antibody is proprietary information.Q96QZ0

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Purification notes-Purity >95%, Storage buffer-pH: 7.4Preservative: 0.03% Proclin 300Constituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Pannexin 3 also known as Panx3 is a part of the pannexin family of proteins and consists of approximately 43 kDa in mass. Mechanically Panx3 forms large-pore channels that facilitate the passage of ions and small molecules across the cell membrane contributing to intercellular communication. This protein is expressed not only in a range of tissues such as the skin bone and cartilage but also in organs like the heart and liver signaling its widespread influence in the body.
Biological function summary
The protein functions at the cellular level include regulation of calcium signaling and ATP release which influences various cell functions. Panx3 often exists as a part of complexes with other similar proteins like connexins which play roles in forming gap junctions. These activities are essential in controlling cellular interactions and maintaining tissue function particularly in supporting cartilage and bone homeostasis.
Pathways
Panx3 influences critical biological processes including the Wnt and PI3K-AKT pathways which are significant in cell proliferation differentiation and survival. Within these pathways Panx3 interacts with proteins such as β-catenin in the Wnt signaling and AKT in the PI3K-AKT pathway. Its activities in these pathways underline its involvement in cellular growth and development processes.
Panx3 has been linked to osteoarthritis and certain cardiac dysfunctions. In osteoarthritis the dysregulation of Panx3 impacts bone and cartilage maintenance as it interacts with proteins such as MMPs (matrix metalloproteinases) that contribute to cartilage breakdown. In cardiac dysfunctions the association of Panx3 with connexins may implicate it in irregular heart signaling. These connections suggest that alterations in this protein's expression or function may lead to pathological conditions in tissues where it is expressed.