Abcam, ab237511, Anti-RIPX antibody

Size: 100µL
Rabbit Polyclonal RIPX antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human RUFY3 aa 200-400.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human RUFY3 aa 200-400. The exact immunogen used to generate this antibody is proprietary information.Q7L099

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Purification notes-Purity greater than 95%., Storage buffer-pH: 7.4Preservative: 0.03% Proclin 300Constituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
RIPX also known as Receptor Interacting Protein X is a signaling protein with a mass of approximately 74 kDa. This protein acts as an important intermediary within various cellular mechanisms. It is expressed in numerous tissues including the spleen liver and the immune system's vital organs. RIPX possesses a death domain which plays a role in the regulation of cellular responses.
Biological function summary
RIPX has significant roles in the immune response and apoptotic processes. RIPX associates with other proteins to form complex structures that modulate cell death and survival ensuring balanced cellular environments. Through its interactions RIPX influences cytokine production and inflammation which are critical aspects of immune system regulation.
Pathways
The signaling mechanisms involving RIPX have been linked closely with the NF-κB and TNF receptor signaling pathways. RIPX acts as an important node working alongside other proteins like RIP1 and TRAF2 to propagate signals that preclude inflammation and apoptosis. Its regulatory function ensures proper communication within cells affecting the balance between cell death and survival in response to external stimuli.
RIPX has connections to inflammatory diseases such as rheumatoid arthritis and Crohn's disease. Dysregulation of RIPX activity can lead to aberrant inflammation linking it to these pathologies. RIPX interactions with proteins like TNF receptor-associated factors can exacerbate inflammatory responses highlighting a potential target for therapeutic intervention in managing chronic inflammation conditions.