Abcam, ab237520, Anti-LANCL2 antibody

Size: 100µg / 100µL
Rabbit Polyclonal LANCL2 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human LANCL2 aa 1-150.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human LANCL2 aa 1-150. The exact immunogen used to generate this antibody is proprietary information.Q9NS86

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Purification notes-Purity >95%, Storage buffer-pH: 7.4Preservative: 0.03% Proclin 300Constituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
LANCL2 also known as Lanthionine Synthetase C-Like 2 is a protein with a molecular weight of approximately 44 kDa. It belongs to the LANCL protein family which also includes LANCL1 and LANCL3. LANCL2 is expressed in various tissues with significant expression observed in adipose tissue liver and skeletal muscle. Its intracellular location suggests a role in cellular processes that require close interaction with intracellular signaling pathways.
Biological function summary
LANCL2 functions in regulatory mechanisms related to metabolic processes. It does not exist in isolation; instead it interacts with other proteins as part of a multiprotein complex. LANCL2 modulates the signaling pathway involving the peroxisome proliferator-activated receptor gamma (PPARγ) and plays a role in modulating glucose and lipid metabolism. Its activity suggests involvement in maintaining cellular energy balance and homeostasis.
Pathways
LANCL2 is integrated into metabolic pathways with significant involvement in both the PPAR signaling pathway and the insulin signaling pathway. These pathways highlight its importance in glucose homeostasis and energy metabolism. LANCL2 interacts with proteins such as AKT an important player in the insulin signaling pathway contributing to the regulation of glucose uptake and lipid metabolism.
LANCL2 has been connected to metabolic diseases particularly type 2 diabetes and obesity. Changes in LANCL2 expression or function can impact glucose and lipid regulation contributing to these conditions. LANCL2's role in these disorders often involves its interaction with proteins like PPARγ which also influences lipid storage and insulin sensitivity. Understanding LANCL2's role in these diseases could provide insights into novel therapeutic approaches.