Abcam, ab237610, Anti-GPR83 antibody

Size: 100µL
Rabbit Polyclonal GPR83 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human GPR83 aa 300 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human GPR83 aa 300 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q9NYM4

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Purification notes-Purity greater than 95%., Storage buffer-pH: 7.4Preservative: 0.03% Proclin 300Constituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
GPR83 also known as GIR or G-protein coupled receptor 83 is a member of the class A rhodopsin-like family of G-protein coupled receptors (GPCRs). This receptor has a mass of approximately 47 kDa. GPR83 is expressed in several tissues with significant expression in the brain particularly in the hypothalamus and to a lesser extent in the cortex and brainstem. It is also found in immune system tissues like the thymus and lymph nodes suggesting roles in both neurological and immune functions.
Biological function summary
GPR83 engages in the regulation of neuroendocrine signaling. There is evidence that it affects appetite control and energy homeostasis implying a role in metabolic processes. GPR83 does not function as part of a larger receptor complex but interacts with other GPCRs or intracellular proteins to transmit extracellular signals into cells. Its activity can modulate synaptic transmission and impact behaviors linked to feeding and stress response.
Pathways
Protein interactions involving GPR83 connect mainly to neuropeptide Y (NPY) signaling and the broader GPCR signaling pathways. The receptor modulates signaling by potentially influencing second messenger systems such as cAMP. Proteins related to these pathways include NPY a neuropeptide that affects energy balance and various G-protein subunits that mediate downstream effects following GPR83 activation.
Altered GPR83 expression or signaling links to obesity and certain psychiatric conditions including anxiety-related disorders. High GPR83 activity has associations with increased fat storage and body weight potentially by downregulating activity through pathways with proteins like NPY and agouti-related peptide (AgRP) which are involved in appetite control. Additionally imbalance in GPR83 signaling might influence mood disorders linked to dysregulation of neural circuits involved in stress and emotion.