Abcam, ab237618, Anti-SorCS1 antibody

Size: 100µL
Rabbit Polyclonal SorCS1 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human SORCS1 aa 1-200.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human SORCS1 aa 1-200. The exact immunogen used to generate this antibody is proprietary information.Q8WY21

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Purification notes-Purity greater than 95%., Storage buffer-pH: 7.4Preservative: 0.03% Proclin 300Constituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
SorCS1 also known as Sortilin-related Vps10 domain containing receptor 1 is a multifunctional protein with a mass of approximately 130 kDa. The protein primarily operates as a sorting receptor within cells influencing protein trafficking. It can bind neurotrophins regulate their transport and manage degradation pathways. SorCS1 is expressed in various tissues including the central nervous system muscle and pancreas. Notably it functions on the cell surface but is also present in distinct intracellular compartments.
Biological function summary
This protein impacts neuronal development and glucose metabolism. SorCS1 belongs to the Vps10p domain receptor family which partakes in protein sorting processes. It is involved in amyloid-beta metabolism and modulates insulin receptor signaling. Through these interactions SorCS1 indirectly affects energy balance and brain function making it significant for neural cell maintenance and metabolic regulation.
Pathways
SorCS1 interacts with cellular mechanisms like insulin signaling and amyloid-beta processing. It modulates the insulin signaling pathway by interacting with the insulin receptor. SorCS1 also influences the amyloid precursor protein (APP) processing pathway impacting the production of amyloid-beta. These pathways link SorCS1 functionally to proteins like sortilin and low-density lipoprotein receptor-related protein 1 (LRP1) highlighting its role in intersecting signaling mechanisms.
Research indicates SorCS1's connection to diabetes and Alzheimer's disease. It can influence the development of type 2 diabetes by modulating insulin signaling pathways and impacting glucose homeostasis. SorCS1 affects the accumulation of amyloid-beta peptides an important factor in Alzheimer's disease progression. SorCS1’s relationships with proteins such as APP and LRP1 deepen its relevance to these conditions presenting it as a potential therapeutic target for intervention.