Abcam, ab237627, Anti-CPNE4 antibody

Size: 100µL
Rabbit Polyclonal CPNE4 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Mouse, Rat, Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human CPNE4 aa 1-300.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:ICC/IF, WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human CPNE4 aa 1-300. The exact immunogen used to generate this antibody is proprietary information.Q96A23

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Purification notes-Purity greater than 95%., Storage buffer-pH: 7.4Preservative: 0.03% Proclin 300Constituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
CPNE4 also known as Copine-4 is a calcium-dependent phospholipid-binding protein. It weighs approximately 66 kDa and plays a role in cellular mechanisms by mediating membrane trafficking processes. CPNE4 is expressed in various tissues with significant presence in the brain indicating its potential role in neurological functions. It acts as a binding partner interacting with phospholipids in a calcium-dependent manner contributing to intra-cellular signaling and vesicle fusion.
Biological function summary
This protein assists in modulating membrane-associated processes and is believed to participate in synaptic plasticity because of its membrane-binding capabilities. CPNE4 could be part of molecular complexes involved in synaptic structuring and function. Evidence suggests it works in conjunction with other proteins involved in neuronal signaling though the exact complexes remain to be fully identified. Its role in membrane dynamics is essential for cellular communication and signaling.
Pathways
CPNE4 engages in pathways such as phosphatidylinositol signaling and synaptic vesicle transport. These pathways are important for ensuring proper neuronal communication and neurotransmitter release. CPNE4 interacts with various proteins within these pathways including kinases and synaptic proteins which together orchestrate complex signaling cascades. Its involvement in these pathways suggests it plays a part in regulating neuronal excitability and synaptic efficacy.
Researchers connect CPNE4 with neurodegenerative conditions and epilepsy due to its influence on synaptic function and brain tissue expression. Studies point to altered CPNE4 activity impacting neuronal stability potentially leading to the progression of such disorders. It may interact with proteins like tau in neurodegenerative diseases where tau pathology disrupts CPNE4-associated pathways exacerbating disease symptoms. Further understanding of CPNE4's role could prove essential in developing therapeutic strategies for these conditions.