Abcam, ab237628, Anti-L3MBTL2 antibody

Size: 100µL
Rabbit Polyclonal L3MBTL2 antibody. Suitable for WB, ICC/IF and reacts with Rat, Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human Lethal(3)malignant brain tumor-like protein 2 aa 1-250.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Rat, Human,
Applications:WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human Lethal(3)malignant brain tumor-like protein 2 aa 1-250. The exact immunogen used to generate this antibody is proprietary information.Q969R5

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Purification notes-Purity greater than 95%., Storage buffer-pH: 7.4Preservative: 0.03% Proclin 300Constituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The L3MBTL2 protein also known as Lethal(3)malignant brain tumor-like protein 2 is a chromatin-binding protein involved in transcriptional repression. It has an approximate mass of 88 kDa. L3MBTL2 plays a role in the Polycomb group of proteins which are known for chromatin modification and gene expression regulation. The protein is broadly expressed in various tissues with higher expression noted in the thymus and testis.
Biological function summary
L3MBTL2 contributes to maintaining gene silencing through its interaction with various chromatin-modifying complexes. As part of the PcG repression complex it binds to modified histones particularly those marked by methylation to suppress transcription. This role is important for proper development and cellular differentiation as it ensures genes turn off or on at the right times during cell cycle and differentiation processes.
Pathways
L3MBTL2 plays key roles in pathways controlling gene expression and cell cycle regulation. Through the Polycomb repressive complex it connects to pathways that influence cellular proliferation and differentiation. L3MBTL2 often interacts with proteins such as RING1B and EZH2 in these pathways facilitating the propagation of chromatin-associated silencing marks that help coordinate complex gene expression programs.
L3MBTL2 is linked to certain cancers and developmental disorders due to its role in gene regulation. Misregulation of L3MBTL2 has been observed in hematopoietic malignancies impacting the normal proliferation of blood cells. It shares connections with proteins like BMI1 in the context of these disorders highlighting its relevance in maintaining the balance of gene expression required for cellular homeostasis and preventing oncogenesis.