Abcam, ab237689, Anti-REEP4 antibody

Size: 100µL
Rabbit Polyclonal REEP4 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human REEP4 aa 50 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human REEP4 aa 50 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q9H6H4

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Purification notes-Purity greater than 95%., Storage buffer-pH: 7.4Preservative: 0.03% Proclin 300Constituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
REEP4 also known as Receptor Expression Enhancing Protein 4 is a protein that assists in shaping the endoplasmic reticulum. It has a molecular mass of approximately 27 kDa. REEP4 is predominantly expressed in various tissues with notable expression in the brain and testes. Through its role REEP4 helps maintain the architecture of organelles essential for proper cellular function.
Biological function summary
In shaping the endoplasmic reticulum REEP4 interacts with other proteins significantly impacting the division and separation of the organelle during cell division. This protein is part of a complex that facilitates the proper distribution of the endoplasmic reticulum in dividing cells. Through these interactions REEP4 ensures that cells maintain proper functionality and organelle distribution which are important in various cellular processes.
Pathways
The endoplasmic reticulum shaping involving REEP4 affects the spindle assembly checkpoint and mitotic division. This involves pathways like those related to cell cycle regulation. REEP4 shares functional connections with proteins such as DPYSL2 and CLIMP-63. These interactions play an essential role in maintaining cellular architecture during mitosis ensuring proper cell division and distribution of cellular contents.
Misregulation of REEP4 can have effects on cell division and may be linked to disorders such as cancer and neurodegenerative diseases. Variations in REEP4 function or expression could influence these conditions due to its role in the structural integrity of the endoplasmic reticulum. Additionally dysfunction in REEP4 can relate to proteins like tau in the context of neurodegenerative diseases suggesting a possible pathophysiological connection through endoplasmic reticulum stress or imbalance during cell cycle processes.