Abcam, ab237739, Anti-NRSN2 antibody

Size: 100µL
Rabbit Polyclonal NRSN2 antibody. Suitable for WB, ICC/IF and reacts with Mouse, Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human NRSN2 aa 1-100.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human NRSN2 aa 1-100. The exact immunogen used to generate this antibody is proprietary information.Q9GZP1

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Purification notes-Purity >95%, Storage buffer-pH: 7.4Preservative: 0.03% Proclin 300Constituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
NRSN2 also known as Neurensin-2 is a small protein with a mass of approximately 24 kDa. It is primarily expressed in the nervous system particularly in neurons. The protein has been observed in certain brain regions and neurons more intensely indicating a role in neural activities. As a transmembrane protein NRSN2 is involved in processes like vesicle trafficking and could influence neurotransmitter release.
Biological function summary
Neurensin-2 plays important roles in neuronal development and synaptic plasticity. It participates in cellular activities that influence neuron signaling and communication. While it does not form part of a larger protein complex it may interact with different cellular structures to regulate membrane dynamics. Such functions suggest its involvement in maintaining synaptic integrity and neuronal network stability important for proper nervous system function.
Pathways
Neurensin-2 is part of neural development and signaling pathways. It contributes significantly to pathways like synaptic transmission and intracellular trafficking integral for neuron communication and plasticity. Through these pathways Neurensin-2 relates to proteins like syntaxin which also influences vesicle docking and neurotransmitter release. These interactions highlight its role in facilitating synaptic connectivity and efficiency.
Neurensin-2 has links to neurodevelopmental disorders and neurodegenerative diseases. Mutations or dysregulation of NRSN2 activity may contribute to conditions like autism spectrum disorders or Alzheimer's disease. The protein has connections to tau proteins which are significant in Alzheimer's pathology indicating that disruptions in NRSN2 function could affect tau dynamics and aggregation. Understanding NRSN2's role may offer insights into potential therapeutic targets for these conditions.