Abcam, ab237778, Anti-Uroplakin IIIB antibody [C362]

Size: 20µg / 100µg / 1mg
Mouse Recombinant Monoclonal Uroplakin IIIB antibody. Suitable for IHC-P, WB and reacts with Mouse samples. Cited in 1 publication.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:C362,
Isotype:IgG2b,
Carrier free:No,
Reacts with:Mouse,
Applications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.

Product details:
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Uroplakin IIIB also known as UPK3B is a specific protein that is part of the family of uroplakins found in the urothelial plaques of bladder epithelium. It has a notable molecular mass of approximately 25 kDa. This protein is mainly expressed in the apical membrane of umbrella cells located in the bladder and other parts of the urinary tract. The expression pattern suggests a role in urothelial differentiation and barrier formation contributing to the impermeability and structural integrity of the urothelium.
Biological function summary
Uroplakin IIIB is an integral part of the urothelial plaque complex. This complex consists of other proteins including Uroplakin Ia Ib and Uroplakin III which work collectively to stabilize the urothelial membrane. Uroplakin IIIB plays an important role in maintaining the barrier function that prevents urine from penetrating deeper layers of tissue thereby protecting underlying tissues from the toxic properties of urine. Its structural contributions are essential in preserving the function and health of the urinary bladder epithelium.
Pathways
Uroplakin IIIB participates in pathways related to epithelial cell differentiation and tight junction formation essential for urothelial homeostasis. It interacts with other uroplakins and is linked to pathways that involve cell adhesion mechanisms. These pathways are important for the establishment of tight junctions necessary for the barrier function of urothelial cells. The coordination and expression of Uroplakin Ia Ib and III in these processes highlight their relationship with Uroplakin IIIB in ensuring cellular cohesion and impermeability.
Alterations in Uroplakin IIIB expression are associated with conditions such as bladder cancer and interstitial cystitis. Dysfunction in the uroplakin protein complex can lead to compromised bladder function and structural abnormalities. In bladder cancer specifically changes in Uroplakin IIIB along with its related proteins like Uroplakin III have been observed and studied as potential biomarkers for tumorigenesis. Understanding these connections provides insights into disease mechanisms and possible therapeutic targets.