Abcam, ab237804, Anti-SFXN4 antibody

Size: 100µg / 100µL
Rabbit Polyclonal SFXN4 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human SFXN4.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Full Length Protein corresponding to Human SFXN4.Q6P4A7

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Purification notes-Purity greater than 95%., Storage buffer-pH: 7.4Preservative: 0.03% Proclin 300Constituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Sideroflexin 4 (SFXN4) also known as mitochondrial iron transporter SLC56A4 is part of the sideroflexin family involved with cellular iron transport within mitochondria. This protein has a molecular mass of approximately 36 kDa. Researchers often study SFXN4 due to its integral role in mitochondrial membranes where it regulates iron homeostasis. SFXN4 shows expression across various tissues with notable presence in heart skeletal muscle and pancreas indicating a widespread role in energy-demanding tissues.
Biological function summary
The SFXN4 protein participates in managing iron import into mitochondrian important for mitochondrial function and overall cellular metabolism. SFXN4 is part of a larger mitochondrial protein complex that includes sideroflexins which together ensure proper iron distribution. This function is essential in maintaining mitochondrial respiration and energy production as mitochondria require iron to produce heme and iron-sulfur clusters necessary for electron transport chain activity.
Pathways
The SFXN4 protein plays a significant role in mitochondrial iron import and homeostasis pathways. It closely interacts with proteins involved in the electron transport chain and is related to other mitochondrial transport systems. One key pathway includes the formation and maintenance of iron-sulfur clusters necessary for electron transport function where SFXN4 cooperates with other mitochondrial proteins like frataxin and ISCU which are vital for cluster assembly.
SFXN4 has implications in disorders where iron metabolism is disrupted such as sideroblastic anemia and Friedreich's ataxia. In these conditions faulty iron transport and mitochondrial iron overload contribute to pathogenesis. Relationships between SFXN4 and proteins like frataxin become important as frataxin deficiency in Friedreich's ataxia leads to impaired mitochondrial function similar to what might be seen with SFXN4 dysfunction. The links between SFXN4 and these disorders make it a potential target for therapeutic intervention and understanding mitochondrial-linked pathologies.