Abcam, ab237845, Anti-GP2 antibody [GP2/1803] - BSA and Azide free

Size: 100µg
Mouse Monoclonal GP2 antibody. Carrier free. Suitable for IHC-P, Protein Array and reacts with Human, Recombinant full length protein - Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human Pancreatic secretory granule membrane major glycoprotein GP2 aa 1-200.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:GP2/1803,
Isotype:IgG2,
Light chain type:kappa,
Carrier free:Yes,
Reacts with:Human,
Applications:IHC-P, Protein ArraySee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human Pancreatic secretory granule membrane major glycoprotein GP2 aa 1-200. The exact immunogen used to generate this antibody is proprietary information.P55259

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A/G, Purification notes-Purified from Bioreactor Concentrate by Protein A/G., Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
GP2 also known as Glycoprotein 2 is an important protein with a molecular mass of about 78 kDa. It mainly expresses in pancreatic acinar cells and the epithelial cells of the gastrointestinal tract. GP2 is anchored to the zymogen granule membrane through a glycosylphosphatidylinositol (GPI) anchor which facilitates its release into the lumen. It plays a mechanical role in the stabilization and release of digestive enzymes contributing to proper digestive processes.
Biological function summary
GP2 interacts with the innate immune system by binding to pathogens such as bacteria. It forms part of the mucosal defense system within the gastrointestinal tract. GP2 acts by trapping pathogens marking them for further immune processing. It also associates with membrane proteins like lactoferrin that help modulate immune response. Through its involvement in pathogen recognition and response GP2 supports a healthy gut environment and prevents infections.
Pathways
GP2 participates in immune-related processes and pathways. One significant pathway includes the mannose-binding lectin (MBL) pathway where GP2 works together with lectins and complement proteins to mediate the identification and clearance of pathogens. GP2's interactions with the complement system overlap with proteins like C3 linking it to a broader immune surveillance network. These interactions position GP2 as a pivotal component in maintaining gut mucosal immunity.
Impaired GP2 function associates with inflammatory bowel disease (IBD) and pancreatitis. Altered expression or mutation of GP2 may compromise defensive capabilities in the gut leading to chronic inflammation as seen in Crohn's disease or ulcerative colitis. Additionally improper GP2 function can result in pancreatitis a condition where enzymes prematurely activate and damage the pancreas. In both disorders GP2’s connection to proteins involved in immune pathways such as lactoferrin and C3 highlights its importance in protecting against excessive inflammation.